Effect of isoflurane anesthesia on hemodynamics following the administration of an angiotensin-converting enzyme inhibitor in cats.

The objective of this study was to evaluate the hemodynamics of the anesthetic isoflurane in healthy cats given angiotensin-converting enzyme inhibitor (ACEI). The 7 healthy young cats and 3 old cats were received placebo or enalapril 0.5 mg/kg orally. The change in systolic arterial pressure from the baseline to 30 min postanesthesia in the ACEI group was significantly higher than in the placebo group (mean +/- SD: -39 +/- 13% vs. -17 +/- 12%, respectively). The present study indicated that general anesthesia may induce hypotension after the administration of an ACEI.